RNA Structures Linked to Parkinson’s Protein Aggregates

Source: NeuroscienceNews.com

Researchers have identified unique RNA structures called G-quadruplexes (G4s) that promote harmful α-synuclein protein aggregation linked to neurodegenerative diseases like Parkinson’s. Elevated calcium levels trigger these G4s, acting as “scaffolds” for α-synuclein clumping. Administering 5-aminolevulinic acid (5-ALA) to model mice prevented aggregation and reduced motor symptoms.

This breakthrough suggests that G4-targeted therapies could offer early intervention for neurodegenerative diseases. The findings may also apply to other conditions involving protein aggregation, such as Alzheimer’s, expanding the potential impact of these treatments. Overall, the study marks a major step forward in neurodegenerative research and therapeutic development.

To learn more, read the full article.

Author: Yasushi Yabuki